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Last Updated: September 22, 2020

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Patent: 7,807,405

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Summary for Patent: 7,807,405
Title:Glycoprotein synthesis and remodeling by enzymatic transglycosylation
Abstract: A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (ENGase), to transfer the oligosaccharide moiety to the acceptor and yield the homogeneous glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of glycoprotein or glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody including a heterogeneous sugar chain, are also described. The disclosed methodology enables glycoprotein drugs to be modified for prolonged half-life in vivo, reduced immunogenicity, and enhanced in vivo activity, and for targeting and drug delivery.
Inventor(s): Wang; Lai-Xi (Ellicott City, MD)
Assignee: University of Maryland Baltimore, Office of Commercial Ventures and Intellectual Property (Baltimore, MD) N/A (N/A)
Application Number:11/760,434
Patent Claims:see list of patent claims

Details for Patent 7,807,405

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial University of Maryland Baltimore, Office of Commercial Ventures and Intellectual Property (Baltimore, MD) N/A (N/A) 2039-02-26 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial University of Maryland Baltimore, Office of Commercial Ventures and Intellectual Property (Baltimore, MD) N/A (N/A) 2039-02-26 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial University of Maryland Baltimore, Office of Commercial Ventures and Intellectual Property (Baltimore, MD) N/A (N/A) 2039-02-26 DISCN search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial University of Maryland Baltimore, Office of Commercial Ventures and Intellectual Property (Baltimore, MD) N/A (N/A) 2039-02-26 RX search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial University of Maryland Baltimore, Office of Commercial Ventures and Intellectual Property (Baltimore, MD) N/A (N/A) 2039-02-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial University of Maryland Baltimore, Office of Commercial Ventures and Intellectual Property (Baltimore, MD) N/A (N/A) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Harvard Business School
AstraZeneca
Colorcon
Mallinckrodt
Express Scripts
Boehringer Ingelheim

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