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Last Updated: September 24, 2020

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Patent: 7,786,273

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Summary for Patent: 7,786,273
Title:Macromolecules comprising a thioether cross-link
Abstract: The present invention provides macromolecules comprising at least one thioether cross-link. A thioether cross-link comprising a single thioether bond between two residues of a macromolecule. The macromolecules of the invention can display enhanced stability, pharmaceutical properties and functional properties. In particular, the invention provides an isolated antibodies comprising at least one thioether cross-link that specifically bind to particular antigens. The present invention also provides a composition comprising a macromolecule substantially free of a denaturing reagent, wherein the macromolecule comprises at least one thioether cross-link. In addition, the present invention provides a method for producing the macromolecules and compositions of the invention.
Inventor(s): Tous; Guillermo I. (East Windsor, NJ), Schenerman; Mark (Reisterstown, MD), Wei; Ziping (North Potomac, MD)
Assignee: Medimmune, LLC (Gaithersburg, MD)
Application Number:11/375,810
Patent Claims:see list of patent claims

Details for Patent 7,786,273

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19   Start Trial Medimmune, LLC (Gaithersburg, MD) 2025-03-14 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 002 1998-06-19   Start Trial Medimmune, LLC (Gaithersburg, MD) 2025-03-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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