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Last Updated: September 22, 2020

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Patent: 7,741,354

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Summary for Patent: 7,741,354
Title:Inhibitors of glutaminyl cyclase
Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, ##STR00001## wherein: R.sup.1 represents heteroaryl, -carbocyclyl-heteroaryl, -alkenylheteroaryl or -alkylheteroaryl; R.sup.2 represents alkyl, which may optionally be substituted by one or more groups selected from amino, halogen, hydroxyl, -alkoxy, -thioalkyl, --C(O)O-alkyl and --C(O)OH; carbocyclyl, which may optionally be substituted by one or more groups selected from alkyl, haloalkyl, amino, halogen, hydroxyl, alkoxy-, -thioalkyl, --C(O)O-alkyl and --C(O)OH; alkenyl; alkynyl; -alkyl-aryl; -alkyl-heteroaryl; -alkyl-heterocyclyl; -alkyl-carbocyclyl; -aryl-heteroaryl; -heteroaryl-aryl; -heteroaryl-heteroaryl; -aryl-aryl; -aryl (monocyclic or bicyclic); heteroaryl (monocyclic or bicyclic); heterocyclyl; or R.sup.2 together with R.sup.4 may form a carbocyclyl group optionally substituted by one or more alkyl groups; R.sup.3 represents alkyl, which may optionally be substituted by one or more groups selected from amino, halogen, hydroxyl, alkoxy-, -thioalkyl, --C(O)OH and --C(O)O-alkyl; carbocyclyl, which may optionally be substituted by one or more groups selected from alkyl, amino, halogen, haloalkyl, hydroxyl, -alkoxy, -thioalkyl, --C(O)OH and --C(O)O-alkyl; alkenyl; -alkyl-aryl; -alkyl(aryl).sub.2, -alkyl(heteroaryl).sub.2, -alkyl(aryl)(heteroaryl), -alkyl-heteroaryl; -alkyl-heterocyclyl which heterocyclyl group may optionally be substituted by one or more groups selected from alkyl, hydroxy and oxo ; -alkyl-carbocyclyl; -aryl-heteroaryl; -heteroaryl-aryl; -aryl-aryl; -aryl-O-aryl, -heteroaryl-heteroaryl; -aryl; heteroaryl; heterocyclyl; -aryl-alkyl-aryl; -aryl-O-alkyl-aryl; -alkyl-C(O)--NH-alkyl-aryl; -alkyl-C(O)--NH-alkyl-heteroaryl; -alkyl-C(O)--NH-alkyl-heterocyclyl; -alkyl-C(O)--(N-piperidinyl) or -alkyl-C(O)--(N-pyrrolidinyl) in which piperidinyl or pyrrolidinyl may optionally be fused to optionally substituted phenyl. R.sup.4 represents H or alkyl.
Inventor(s): Thormann; Michael (Martinsried, DE), Altmstetter; Michael (Martinsried, DE), Treml; Andreas (Martinsried, DE), Heiser; Ulrich (Halle/Saale, DE), Buchholz; Mirko (Halle/Saale, DE)
Assignee: Probiodrug AG (Halle-Saale, DE)
Application Number:11/937,159
Patent Claims:see list of patent claims

Details for Patent 7,741,354

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial Probiodrug AG (Halle-Saale, DE) 2039-02-26 search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07   Start Trial Probiodrug AG (Halle-Saale, DE) 2039-02-26 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07   Start Trial Probiodrug AG (Halle-Saale, DE) 2039-02-26 RX Orphan search
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 003 2001-05-07   Start Trial Probiodrug AG (Halle-Saale, DE) 2039-02-26 RX Orphan search
Biogen Idec TYSABRI natalizumab VIAL; SINGLE-USE 125104 001 2004-11-23   Start Trial Probiodrug AG (Halle-Saale, DE) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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