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Last Updated: September 29, 2020

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Patent: 7,737,260

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Summary for Patent: 7,737,260
Title:Protein complex using an immunoglobulin fragment and method for the preparation thereof
Abstract: Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
Inventor(s): Kim; Young Min (Yongin-si, KR), Kim; Dae Jin (Seocho-gu, KR), Bae; Sung Min (Seocho-gu, KR), Lim; Chang Ki (Suwon-si, KR), Kwon; Se Chang (Gwangjin-gu, KR), Lee; Gwan Sun (Songpa-gu, KR)
Assignee: Hanmi Pharm. Co., Ltd (Hwaseong-si, KR)
Application Number:10/535,232
Patent Claims:see list of patent claims

Details for Patent 7,737,260

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial Hanmi Pharm. Co., Ltd (Hwaseong-si, KR) 2023-11-13 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial Hanmi Pharm. Co., Ltd (Hwaseong-si, KR) 2023-11-13 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial Hanmi Pharm. Co., Ltd (Hwaseong-si, KR) 2023-11-13 DISCN search
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Hanmi Pharm. Co., Ltd (Hwaseong-si, KR) 2023-11-13 RX search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Hanmi Pharm. Co., Ltd (Hwaseong-si, KR) 2023-11-13 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Hanmi Pharm. Co., Ltd (Hwaseong-si, KR) 2023-11-13 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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