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Last Updated: October 26, 2021

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Patent: 7,723,485

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Summary for Patent: 7,723,485
Title:Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates
Abstract: Cysteine engineered anti-MUC16 antibodies are engineered by replacing one or more amino acids of a parent anti-MUC16 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-MUC16 antibodies are provided. Cysteine engineered anti-MUC16 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-MUC16 antibody-drug conjugates having Formula I: Ab-(L-D).sub.p I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
Inventor(s): Junutula; Jagath R. (Fremont, CA), Mallet; William (Redwood City, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:12/116,457
Patent Claims:see list of patent claims

Details for Patent 7,723,485

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. AVASTIN bevacizumab Injection 125085 2004-02-26 ⤷  Free Forever Trial 2039-02-26
Genentech, Inc. PERJETA pertuzumab Injection 125409 2012-06-08 ⤷  Free Forever Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Boehringer Ingelheim

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