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Last Updated: July 11, 2020

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Patent: 7,713,737

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Summary for Patent: 7,713,737
Title:Methods and compositions for needleless delivery of macromolecules
Abstract: Methods and compositions for needleless delivery of macromolecules to the bloodstream of a subject are provided herein. In one aspect, the invention provides a delivery construct, comprising a receptor binding domain, a transcytosis domain, a macromolecule to be delivered to a subject, and a cleavable linker. In certain aspects, the cleavable linker can be cleavable by an enzyme present in higher concentration at or near the basal-lateral membrane of a polarized epithelial cell or in the plasma than elsewhere in the body, for example, at the apical side of the polarized epithelial cell. In other aspects, the invention provides nucleic acids encoding delivery constructs of the invention, kits comprising delivery constructs of the invention, cells expressing delivery constructs of the invention, and methods of using delivery constructs of the invention.
Inventor(s): Mrsny; Randall J. (Los Altos Hills, CA)
Assignee: Trinity Biosystems, Inc. (Menlo Park, CA)
Application Number:11/244,349
Patent Claims:see list of patent claims

Details for Patent 7,713,737

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Trinity Biosystems, Inc. (Menlo Park, CA) 2024-10-04 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Trinity Biosystems, Inc. (Menlo Park, CA) 2024-10-04 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Trinity Biosystems, Inc. (Menlo Park, CA) 2024-10-04 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Trinity Biosystems, Inc. (Menlo Park, CA) 2024-10-04 RX Orphan search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial Trinity Biosystems, Inc. (Menlo Park, CA) 2024-10-04 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial Trinity Biosystems, Inc. (Menlo Park, CA) 2024-10-04 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Baxter
AstraZeneca
Moodys
Harvard Business School
McKesson
Johnson and Johnson

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