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Last Updated: September 24, 2020

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Patent: 7,713,573

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Summary for Patent: 7,713,573
Title:Method for loading nanoporous layers with therapeutic agent
Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
Inventor(s): Owens; Gary K. (Earlysville, VA), Wamhoff; Brian R. (Charlottesville, VA), Hudson; Matthew S. (Charlottesville, VA), Lye; Whye-Kei (Charlottesville, VA), Spradlin; Joshua (Charlottesville, VA), Reed; Michael (Charlottesville, VA), Looi; Kareen (Charlottesville, VA)
Assignee: Medtronic Vascular, Inc. (Santa Rosa, CA)
Application Number:11/352,436
Patent Claims:see list of patent claims

Details for Patent 7,713,573

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial Medtronic Vascular, Inc. (Santa Rosa, CA) 2022-11-13 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial Medtronic Vascular, Inc. (Santa Rosa, CA) 2022-11-13 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial Medtronic Vascular, Inc. (Santa Rosa, CA) 2022-11-13 DISCN search
Genentech ACTIVASE alteplase VIAL; SINGLE-USE 103172 001 1987-11-13   Start Trial Medtronic Vascular, Inc. (Santa Rosa, CA) 2022-11-13 RX search
Genentech ACTIVASE alteplase VIAL; SINGLE-USE 103172 002 1987-11-13   Start Trial Medtronic Vascular, Inc. (Santa Rosa, CA) 2022-11-13 RX search
Genentech CATHFLO ACTIVASE alteplase VIAL 103172 003 1987-11-13   Start Trial Medtronic Vascular, Inc. (Santa Rosa, CA) 2022-11-13 RX search
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22   Start Trial Medtronic Vascular, Inc. (Santa Rosa, CA) 2022-11-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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