Patent: 7,713,573
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Summary for Patent: 7,713,573
Title: | Method for loading nanoporous layers with therapeutic agent |
Abstract: | The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings. |
Inventor(s): | Owens; Gary K. (Earlysville, VA), Wamhoff; Brian R. (Charlottesville, VA), Hudson; Matthew S. (Charlottesville, VA), Lye; Whye-Kei (Charlottesville, VA), Spradlin; Joshua (Charlottesville, VA), Reed; Michael (Charlottesville, VA), Looi; Kareen (Charlottesville, VA) |
Assignee: | Medtronic Vascular, Inc. (Santa Rosa, CA) |
Application Number: | 11/352,436 |
Patent Claims: | see list of patent claims |
Details for Patent 7,713,573
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Microbix Biosystems Inc. | KINLYTIC | urokinase | For Injection | 021846 | 01/16/1978 | ⤷ Try a Trial | 2022-11-13 |
Genentech, Inc. | ACTIVASE | alteplase | For Injection | 103172 | 11/13/1987 | ⤷ Try a Trial | 2022-11-13 |
Genentech, Inc. | CATHFLO ACTIVASE | alteplase | For Injection | 103172 | 09/04/2001 | ⤷ Try a Trial | 2022-11-13 |
Janssen Biotech, Inc. | REOPRO | abciximab | Injection | 103575 | 12/22/1994 | ⤷ Try a Trial | 2022-11-13 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |