Patent: 7,659,445

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Summary for Patent: 7,659,445

Title:	Expression of plasminogen and microplasminogen in duck weed
Abstract:	The present invention provides methods and compositions for the production of recombinant plasminogen, microplasminogen, and fragments thereof in a duckweed expression system. It is the novel finding of the present invention that a duckweed expression system may be used to produce high levels of plasminogen and microplasminogen. The duckweed-produced plasminogen and microplasminogen can be activated to produce a polypeptide having protease activity. Thus, the invention encompasses methods for the expression of plasminogen, microplasminogen, and fragments thereof in duckweed, duckweed plants that are transformed with expression cassettes for the expression of plasminogen, microplasminogen, and fragments thereof, and nucleic acids comprising nucleotide sequences encoding plasminogen, microplasminogen, and fragments thereof, where these nucleotide sequences are modified to enhance their expression in duckweed.
Inventor(s):	Spencer; David (Chapel Hill, NC), Dickey; Lynn F. (Cary, NC), Gasdaska; John R. (Carrboro, NC), Wang; Xiaowei (Carrboro, NC), Cox; Kevin M. (Raleigh, NC), Peele; Charles G. (Apex, NC)
Assignee:	Biolex Therapeutics, Inc. (Pittsboro, NC)
Application Number:	11/056,621
Patent Claims:	see list of patent claims

Details for Patent 7,659,445

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	See Plans and Pricing	2024-02-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		See Plans and Pricing	2024-02-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		See Plans and Pricing	2024-02-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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