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Last Updated: October 1, 2020

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Patent: 7,659,112

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Summary for Patent: 7,659,112
Title:Process for producing physiologically active protein using genetically modified silkworm
Abstract: The present invention provides a genetic engineering material for insects that enables a target protein to be purified easily, without requiring the use of recombinant baculovirus, while simultaneously providing a process for producing exogenous protein using that genetic engineering material. A gene recombinant silkworm is obtained by inserting an exogenous protein gene such as a cytokine gene coupled to a promoter that functions in silk glands into a silkworm chromosome. An exogenous protein such as a cytokine is then extracted and purified from the silk glands or cocoon of that silkworm or its offspring. A large amount of exogenous protein can be produced within silk gland cells, outside silk gland cells or in silk thread or a cocoon by inserting an expression gene cassette, in which the DNA sequence of the 3\' terminal portion and the DNA sequence of the 5\' terminal portion of fibroin H chain gene are fused to the exogenous protein gene, into silk gland cells and so forth.
Inventor(s): Hiramatsu; Shingo (Nagoya, JP), Tanaka; Takashi (Nagoya, JP), Yamada; Katsushige (Aichi, JP), Tamura; Toshiki (Ushiku, JP)
Assignee: Toray Industries, Inc. (Tokyo, JP)
Application Number:10/506,327
Patent Claims:see list of patent claims

Details for Patent 7,659,112

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Toray Industries, Inc. (Tokyo, JP) 2022-03-06 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Toray Industries, Inc. (Tokyo, JP) 2022-03-06 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Toray Industries, Inc. (Tokyo, JP) 2022-03-06 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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