Patent: 7,645,449

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Summary for Patent: 7,645,449

Title:	Sensitizing cells for apoptosis by selectively blocking cytokines
Abstract:	The invention refers to the use of a cytokine antagonist which modulates the expression and/or the function of a cytokine, particularly a Th2 helper cell cytokine, in a cell and causes the down-regulation of anti-apoptotic proteins in said cell through the cytokine modulation for sensitizing cells for apoptosis. In particular, the cells that can be treated with the cytokine antagonists are drug-resistant cancer cells which fail to undergo apoptosis.
Inventor(s):	Stassi; Giorgio, N/A (IT-90127 Palermo, IT), Todaro; Matilde, N/A (IT-90127 Palermo, IT)
Assignee:
Application Number:	10/544,794
Patent Claims:	see list of patent claims

Details for Patent 7,645,449

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Merck	ELSPAR	asparaginase	VIAL	101063	001	1978-01-10	➤ Sign Up		2023-02-07	RX		search
Sigma Tau	ONCASPAR	pegaspargase	VIAL	103411	001	1994-02-01	➤ Sign Up		2023-02-07	RX		search
Genentech	RITUXAN	rituximab	VIAL	103705	001	1997-11-26	➤ Sign Up		2023-02-07	RX		search
Genentech	HERCEPTIN	trastuzumab	VIAL; INTRAVENOUS	103792	001	1998-09-25	➤ Sign Up		2023-02-07	RX	Orphan	search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 7,645,449

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Country	Patent Number	Publication Date
Austria	396741	Jun 15, 2008
Australia	2004210432	Aug 19, 2004
Australia	2004210432	Dec 18, 2008
Canada	2515302	Aug 19, 2004
>Country	>Patent Number	>Publication Date

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