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Last Updated: August 11, 2020

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Patent: 7,632,983

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Summary for Patent: 7,632,983
Title:Expression of monoclonal antibodies in duckweed
Abstract: Methods, nucleic acid sequences, and transformed duckweed plant or duckweed nodule cultures for the expression and the secretion of biologically active polypeptides from genetically engineered duckweed are provided. Expression of recombinant polypeptides in duckweed is improved by modifying the nucleotide sequence of the expression cassette encoding the polypeptide for improved expression in duckweed. Recovery of biologically active polypeptides from duckweed is improved by linking the biologically active polypeptide to a signal peptide that directs the secretion of the polypeptide into the culture medium. Methods of producing recombinant monoclonal antibodies having effector function, and antibodies produced by these methods are provided.
Inventor(s): Dickey; Lynn F. (Cary, NC), Gasdaska; John R. (Carrboro, NC), Cox; Kevin M. (Raleigh, NC), Peele; Charles G. (Apex, NC), Spencer; David (Chapel Hill, NC)
Assignee: Biolex Therapeutics, Inc. (Durham, NC)
Application Number:10/794,615
Patent Claims:see list of patent claims

Details for Patent 7,632,983

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Biolex Therapeutics, Inc. (Durham, NC) 2020-07-31 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Biolex Therapeutics, Inc. (Durham, NC) 2020-07-31 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Biolex Therapeutics, Inc. (Durham, NC) 2020-07-31 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Colorcon
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Mallinckrodt
Merck
Johnson and Johnson
McKinsey

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