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Last Updated: January 20, 2020

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Patent: 7,550,143

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Summary for Patent: 7,550,143
Title:Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
Abstract: The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor. The precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. Other embodiments concern tetramers comprising a first and second homodimer, which may be identical or different. The disclosed methods and compositions provide a facile and general way to obtain homodimers, homotetramers and heterotetramers of virtually any functionality and/or binding specificity.
Inventor(s): Chang; Chien Hsing (Downingtown, PA), Goldenberg; David M. (Mendham, NJ), McBride; William J. (Boonton, NJ), Rossi; Edmund A. (Nutley, NJ)
Assignee: IBC Pharmaceuticals, Inc. (Morris Plains, NJ)
Application Number:11/389,358
Patent Claims:see list of patent claims

Details for Patent 7,550,143

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech XOLAIR omalizumab VIAL 103976 001 2003-06-20   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-04-06 RX search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-04-06 RX Orphan search
Medimmune SYNAGIS palivizumab VIAL 103770 002 1998-06-19   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-04-06 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-04-06 RX search
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-04-06 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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