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Generated: July 17, 2019

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Patent: 7,550,143

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Summary for Patent: 7,550,143
Title:Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
Abstract: The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor. The precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. Other embodiments concern tetramers comprising a first and second homodimer, which may be identical or different. The disclosed methods and compositions provide a facile and general way to obtain homodimers, homotetramers and heterotetramers of virtually any functionality and/or binding specificity.
Inventor(s): Chang; Chien Hsing (Downingtown, PA), Goldenberg; David M. (Mendham, NJ), McBride; William J. (Boonton, NJ), Rossi; Edmund A. (Nutley, NJ)
Assignee: IBC Pharmaceuticals, Inc. (Morris Plains, NJ)
Application Number:11/389,358
Patent Claims:see list of patent claims

Details for Patent 7,550,143

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Genentech XOLAIR omalizumab VIAL 103976 001 2003-06-20 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) ➤ Sign Up RX search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) ➤ Sign Up RX Orphan search
Medimmune SYNAGIS palivizumab VIAL 103770 002 1998-06-19 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) ➤ Sign Up RX search
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) ➤ Sign Up RX search
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) ➤ Sign Up RX search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
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Federal Trade Commission
Cantor Fitzgerald
Express Scripts
Mallinckrodt

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