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Last Updated: December 5, 2021

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Patent: 7,541,342

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Summary for Patent: 7,541,342
Title:Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents
Abstract: Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-.delta. to the mitochondria and the phosphorylation of mitochondrial phospholipid scramblase 3. The compounds also provide cardioprotection through the translocation and activation of protein kinase C-.epsilon. in cardiomyocytes, thereby inhibiting apoptosis in carciomyocytes.
Inventor(s): Lothstein; Leonard (Eads, TN), Israel; Mervyn (Germantown, TN), Sweatman; Trevor (Memphis, TN), Hofmann; Polly A. (Memphis, TN)
Assignee: University of Tennessee Research Foundation (Knoxville, TN)
Application Number:11/369,225
Patent Claims:see list of patent claims

Details for Patent 7,541,342

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Try it Free 2025-03-04
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Try it Free 2025-03-04
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 2019-02-28 ⤷  Try it Free 2025-03-04
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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