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Last Updated: September 18, 2020

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Patent: 7,541,342

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Summary for Patent: 7,541,342
Title:Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents
Abstract: Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-.delta. to the mitochondria and the phosphorylation of mitochondrial phospholipid scramblase 3. The compounds also provide cardioprotection through the translocation and activation of protein kinase C-.epsilon. in cardiomyocytes, thereby inhibiting apoptosis in carciomyocytes.
Inventor(s): Lothstein; Leonard (Eads, TN), Israel; Mervyn (Germantown, TN), Sweatman; Trevor (Memphis, TN), Hofmann; Polly A. (Memphis, TN)
Assignee: University of Tennessee Research Foundation (Knoxville, TN)
Application Number:11/369,225
Patent Claims:see list of patent claims

Details for Patent 7,541,342

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial University of Tennessee Research Foundation (Knoxville, TN) 2025-03-04 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial University of Tennessee Research Foundation (Knoxville, TN) 2025-03-04 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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