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Last Updated: August 11, 2020

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Patent: 7,507,704

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Summary for Patent: 7,507,704
Title:Receptor modulated cancer protocols
Abstract: The present invention discloses that prior art protocols that administer HER receptor blockers concurrently with phase specific cytotoxic chemotherapeutics result in antagonistic function that prevents subsequent administrations of phase specific cytotoxic from functioning. The present invention provides protocols that allow the two classes of drugs to function synergistically. Moreover, the present invention also identifies that gompertzian tumor growth results in heterogeneity of cell cycle times in a tumor and that chemotherapeutic depopulation of the tumor results in accelerating cell cycle times, both of which preclude synchronicity of successive administrations of S-Phase cytotoxics relative to the progression of the S-Phase in the cancer cell population under prior art protocols. Present invention provides novel \"synchronous\" protocols for S-Phase cytotoxics, using HER blockers, to overcome this problem. Present invention also discloses how to integrate protocols of U.S. Pat. No. 6,486,146 for HER+ cancers that are also endocrine dependent.
Inventor(s): Zamoyski; Mark (San Jose, CA)
Application Number:11/809,264
Patent Claims:see list of patent claims

Details for Patent 7,507,704

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Start Trial 2022-11-15 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial 2022-11-15 RX Orphan search
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial 2022-11-15 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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