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Last Updated: September 23, 2020

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Patent: 7,491,403

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Summary for Patent: 7,491,403
Title:Pharmaceutical botulinum toxin compositions
Abstract: Botulinum toxin, a well know systemic poison, produces favorable therapeutic effect by virtue of regionally attaching to nerves within the myoneural junction and possibly other tissues in a target region of a particular tissue. The present invention provides compositions of botulinum toxin and a sequestration agent that increase sequestration and delivery of the botulinum toxin to neural and associated tissues, as compared with available formulations of botulinum toxins, and thereby produce a beneficial clinical effect. The sequestration agents of the present invention include proteins, lipids and carbohydrates. A preferred composition of the present invention comprises a botulinum toxin and an albumin. The present invention also provides methods of treating neuromuscular diseases and pain using the disclosed compositions and methods of making the disclosed compositions.
Inventor(s): Borodic; Gary (Canton, MA)
Assignee: Botulinum Toxin Research Associates (Quincy, MA)
Application Number:10/740,755
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,491,403
Patent Claims:see list of patent claims

Details for Patent 7,491,403

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Grifols Usa, Llc PLASBUMIN albumin (human) SOLUTION 101138 1 1994-09-26   Start Trial Botulinum Toxin Research Associates (Quincy, MA) 2022-12-20 search
Baxalta Us Inc. FLEXBUMIN albumin human INJECTION, SOLUTION 101452 1 2014-07-31   Start Trial Botulinum Toxin Research Associates (Quincy, MA) 2022-12-20 search
Csl Behring Ag ALBURX albumin (human) SOLUTION 102366 1 2009-01-06   Start Trial Botulinum Toxin Research Associates (Quincy, MA) 2022-12-20 search
Grifols Usa, Llc ALBUTEIN albumin (human) INJECTION, SOLUTION 102478 1 2019-12-15   Start Trial Botulinum Toxin Research Associates (Quincy, MA) 2022-12-20 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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