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Last Updated: November 27, 2021

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Patent: 7,485,769

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Summary for Patent: 7,485,769
Title:Transgenic mammals
Abstract: This invention provides a nonhuman transgenic mammal carrying transgene comprising the regulatory genes capable of functioning in the hyperacute rejection-occurring local cells and gene encoding human N-acetylglucosaminyltransferase III (GnT-III), or a nonhuman transgenic mammal carrying transgene comprising the regulatory genes and genes encoding GnT-III and the human complement inhibitor. Because of reduced .alpha.-Gal antigens in the hyperacute rejection-occurring local cells or because of both reduced .alpha.-Gal antigens and expression of the human complement inhibitor, the transgenic mammal of this invention can effectively inhibit the hyperacute rejection caused by discordant xenotransplantation. Consequently, this invention provides the transgenic mammal suitable for organ transplantation.
Inventor(s): Murakami; Hiroshi (Tsukuba, JP), Fujimura; Tatsuya (Tsukuba, JP), Takahagi; Yoichi (Tsukuba, JP), Toyomura; Koji (Tsukuba, JP), Shigehisa; Tamotsu (Tsukuba, JP)
Assignee: Nippon Meat Packers, Inc. (Osaka-shi, JP)
Application Number:10/362,429
Patent Claims:see list of patent claims

Details for Patent 7,485,769

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2020-08-25
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2020-08-25
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Express Scripts
Mallinckrodt
Johnson and Johnson
Colorcon
Dow
McKinsey

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