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Last Updated: July 11, 2020

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Patent: 7,482,323

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Summary for Patent: 7,482,323
Title:Intracellular interleukin-1 receptor antagonist and uses thereof
Abstract: Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over-expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients.
Inventor(s): Hasty; Karen A. (Memphis, TN), Postlethwaite; Arnold (Eads, TN), Kanangat; Sivadasan (Cordova, TN)
Assignee: The University of Tennessee Research Foundation (Knoxville, TN)
Application Number:11/072,170
Patent Claims:see list of patent claims

Details for Patent 7,482,323

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial The University of Tennessee Research Foundation (Knoxville, TN) 2024-03-04 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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