Patent: 7,439,230

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Summary for Patent: 7,439,230

Title:	Methods of treatment using CTLA4 mutant molecules
Abstract:	The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.
Inventor(s):	Peach; Robert J. (San Diego, CA), Naemura; Joseph R. (Bellevue, WA), Linsley; Peter S. (Seattle, WA), Bajorath; Jurgen (Lynwood, WA)
Assignee:	Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:	10/980,742
Patent Claims:	see list of patent claims

Details for Patent 7,439,230

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Novartis Pharmaceuticals Corporation	SIMULECT	basiliximab	For Injection	103764	05/12/1998	See Plans and Pricing	2020-05-26
Novartis Pharmaceuticals Corporation	SIMULECT	basiliximab	For Injection	103764	01/02/2003	See Plans and Pricing	2020-05-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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