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Last Updated: December 5, 2021

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Patent: 7,439,230

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Summary for Patent: 7,439,230
Title:Methods of treatment using CTLA4 mutant molecules
Abstract: The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.
Inventor(s): Peach; Robert J. (San Diego, CA), Naemura; Joseph R. (Bellevue, WA), Linsley; Peter S. (Seattle, WA), Bajorath; Jurgen (Lynwood, WA)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:10/980,742
Patent Claims:see list of patent claims

Details for Patent 7,439,230

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Novartis Pharmaceuticals Corporation SIMULECT basiliximab For Injection 103764 1998-05-12 ⤷  Try it Free 2020-05-26
Novartis Pharmaceuticals Corporation SIMULECT basiliximab For Injection 103764 2003-01-02 ⤷  Try it Free 2020-05-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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