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Last Updated: July 11, 2020

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Patent: 7,439,057

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Summary for Patent: 7,439,057
Title:Convective flow tissue assembly
Abstract: The present invention provides for an improved in vitro tissue assembly system and related methods that includes and uses a bioreactor, a porous mandrel disposed in the bioreactor, and components that provide for the circulation of culture media and cell suspensions within the bioreactor and through the porous mandrel. The circulation of the culture media and cell suspensions within the bioreactor produces a radial, convective flow and drag forces that result in the deposition of cells on the mandrel to form a tissue construct. Upon completion of the culture and tissue formation process, the tissue construct may be removed from the mandrel for subsequent in vivo use.
Inventor(s): Frangos; John A. (La Jolla, CA), Sobolewski; Peter (San Diego, CA)
Assignee: La Jolla Bioengineering Institute (La Jolla, CA)
Application Number:10/991,079
Patent Claims:see list of patent claims

Details for Patent 7,439,057

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial La Jolla Bioengineering Institute (La Jolla, CA) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Mallinckrodt
Express Scripts
Medtronic
Colorcon
McKesson
Johnson and Johnson

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