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Last Updated: September 27, 2020

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Patent: 7,427,689

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Summary for Patent: 7,427,689
Title:ErbB-2 selective small molecule kinase inhibitors
Abstract: A novel method for erbB-2 kinase inhibition by compounds identifies through computational modeling and data processing and/or rational and de novo drug design is provided the compounds bind erbB-2 kinase molecules and which can be used as erbB-2 kinase agonists or antagonists. These compounds are useful especially in the treatment of cancer, particularly breast cancer, and can be used alone or in combination with other chemotherapeutic agents, particularly with hercetin, a humanized anti-HER-2 antibody, or with radiation therapy. A specific compound which is exemplified is \"compound B17\"=methyl-(p-nitrophenyl)-2-propynoate.
Inventor(s): Wang; Shaomeng (Saline, MI), Yang; Dajun (Rockville, MD), Enyedy; Istvan (Hamden, CT)
Assignee: Georgetown University (Washington, DC)
Application Number:10/343,267
Patent Claims:see list of patent claims

Details for Patent 7,427,689

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Georgetown University (Washington, DC) 2020-07-28 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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