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Last Updated: July 5, 2020

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Patent: 7,419,808

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Summary for Patent: 7,419,808
Title:Methods and compositions for the production of adenoviral vectors
Abstract: The present invention addresses the need to improve the yield of adenovirus when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of infection temperatures lower than 37.degree. C. in a cell culture system results in improved yields of adenovirus. In addition, it has been demonstrated that when host cells are grow in a bioreactor, initiating adenovirus infection by diluting the host cells with fresh media and adenovirus results in improved yield of adenovirus. Methods of adenoviral production and purification using infection temperatures less than 37.degree. C. are disclosed. Methods of adenoviral production and purification wherein the host cells are grown in a bioreactor and adenovirus infection is initiated by diluting the host cells with fresh media and adenovirus are also disclosed.
Inventor(s): Zhang; Shuyuan (Sugar Land, TX), Pham; Hai (Houston, TX)
Assignee: Introgen Therapeutics, Inc. (Austin, TX)
Application Number:11/079,986
Patent Claims:see list of patent claims

Details for Patent 7,419,808

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Introgen Therapeutics, Inc. (Austin, TX) 2023-05-15 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Introgen Therapeutics, Inc. (Austin, TX) 2023-05-15 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Introgen Therapeutics, Inc. (Austin, TX) 2023-05-15 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Introgen Therapeutics, Inc. (Austin, TX) 2023-05-15 RX Orphan search
Akorn Inc HYDASE hyaluronidase INJECTABLE;INJECTION 021716 001 2005-10-25   Start Trial Introgen Therapeutics, Inc. (Austin, TX) 2023-05-15 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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