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Last Updated: July 11, 2020

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Patent: 7,361,740

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Summary for Patent: 7,361,740
Title:Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
Abstract: The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified antibody.
Inventor(s): Hinton; Paul R. (Sunnyvale, CA), Tsurushita; Naoya (Palo Alto, CA), Tso; J. Yun (Menlo Park, CA), Vasquez; Maximiliano (Palo Alto, CA)
Assignee: PDL BioPharma, Inc. (Redwood City, CA)
Application Number:10/822,300
Patent Claims:see list of patent claims

Details for Patent 7,361,740

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Biogen ZINBRYTA daclizumab INJECTABLE;INJECTION 761029 001 2017-05-26   Start Trial PDL BioPharma, Inc. (Redwood City, CA) 2022-10-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 7,361,740

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