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Last Updated: February 25, 2020

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Patent: 7,271,143

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Summary for Patent: 7,271,143
Title:Peptides for regulation of urokinase (uPA) and tissue type (tPA) plasminogen activator and method of optimizing therapeutic efficacy
Abstract: Compositions of the polypeptide SEQ ID NO:1, SEQ ID NO:2, anti-LRP antibodies, LRP antagonists, and/or one or more fibrinolytic agents are formulated for enhancing the fibrinolytic activity, reducing the side effects due to vasoactivity caused by the fibrinolytic agents, and/or prolonging the half lives of the fibrinolytic agents. The invention further relates to combination compositions and/or therapy regimens, comprising the polypeptide SEQ ID NO:1 and/or SEQ ID NO:2 and one or more currently used plasminogen activators.
Inventor(s): Higazi; Abd. Al-Roof (Shimshon, IL)
Assignee: Thrombotech Ltd. (Nazareth Illit, IL)
Application Number:10/386,777
Patent Claims:see list of patent claims

Details for Patent 7,271,143

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech ACTIVASE alteplase VIAL; SINGLE-USE 103172 001 1987-11-13   Start Trial Thrombotech Ltd. (Nazareth Illit, IL) 2021-07-10 RX search
Genentech ACTIVASE alteplase VIAL; SINGLE-USE 103172 002 1987-11-13   Start Trial Thrombotech Ltd. (Nazareth Illit, IL) 2021-07-10 RX search
Genentech CATHFLO ACTIVASE alteplase VIAL 103172 003 1987-11-13   Start Trial Thrombotech Ltd. (Nazareth Illit, IL) 2021-07-10 RX search
Ekr Therap RETAVASE reteplase VIAL 103786 001 1998-05-06   Start Trial Thrombotech Ltd. (Nazareth Illit, IL) 2021-07-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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