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Last Updated: September 18, 2020

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Patent: 7,262,287

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Summary for Patent: 7,262,287
Title:Hansenula polymorpha yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same
Abstract: The present invention relates to a nucleic acid molecule comprising the HpYPS1 gene encoding H. polymorpha yapsin1, a polypeptide encoded by the nucleic acid molecule, a H. polymorpha mutant strain having reduced yapsin activity by mutation of the HpYPS gene encoding H. polymorpha yapsin1, a recombinant H. polymorpha strain expressing a foreign protein produced by introducing a gene encoding the foreign protein into the H. polymorpha mutant strain, and a process for preparing a foreign protein comprising culturing the recombinant H. polymorpha strain under conditions to express the foreign protein and isolating the foreign protein from the culture.
Inventor(s): Kang; Hyun-Ah (Daejeon, KR), Rhee; Sang-Ki (Daejeon, KR), Sohn; Min-Jeong (Daejeon, KR), Kim; Jeong-Yoon (Daejeon, KR)
Assignee: Korea Research Institute of Bioscience and Biotechnology (Daejeon, KR) Leadbio, Inc. (Daejeon, KR) Bioholdings Co., Ltd. (Daejeon, KR)
Application Number:10/518,377
Patent Claims:see list of patent claims

Details for Patent 7,262,287

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Korea Research Institute of Bioscience and Biotechnology (Daejeon, KR) Leadbio, Inc. (Daejeon, KR) Bioholdings Co., Ltd. (Daejeon, KR) 2022-06-29 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Korea Research Institute of Bioscience and Biotechnology (Daejeon, KR) Leadbio, Inc. (Daejeon, KR) Bioholdings Co., Ltd. (Daejeon, KR) 2022-06-29 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Korea Research Institute of Bioscience and Biotechnology (Daejeon, KR) Leadbio, Inc. (Daejeon, KR) Bioholdings Co., Ltd. (Daejeon, KR) 2022-06-29 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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