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Last Updated: September 29, 2020

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Patent: 7,229,755

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Summary for Patent: 7,229,755
Title:Method for detection of alterations in the DNA mismatch repair pathway
Abstract: We have now discovered that eukaryotes, including mammals, have a DNA mismatch repair pathway analogous to the pathway that exists in bacteria. Defects or alterations in this mismatch repair pathway in a mammal, such as a human, will result in the accumulation of unstable repeated DNA sequences. Such a phenotype has a high correlation to disease state in a number of cancers, such as hereditary colon cancers. Accordingly, discovering a defect or alteration in the pathway can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.
Inventor(s): Kolodner; Richard D. (Jamaica Plain, MA), Reenan; Robert A. G. (Madison, WI), Fishel; Richard (Penn Valley, PA)
Assignee: Dana Farber Cancer Institute, Inc. (Boston, MA) University of Vermont and State Agricultural College (Burlington, VT)
Application Number:08/448,444
Patent Claims:see list of patent claims

Details for Patent 7,229,755

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Dana Farber Cancer Institute, Inc. (Boston, MA) University of Vermont and State Agricultural College (Burlington, VT) 2024-06-12 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Dana Farber Cancer Institute, Inc. (Boston, MA) University of Vermont and State Agricultural College (Burlington, VT) 2024-06-12 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Dana Farber Cancer Institute, Inc. (Boston, MA) University of Vermont and State Agricultural College (Burlington, VT) 2024-06-12 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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