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Generated: September 18, 2019

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Patent: 7,186,399

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Summary for Patent: 7,186,399
Title:Methods for targeted drug delivery
Abstract: A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
Inventor(s): Lanza; Gregory M. (St. Louis, MO), Wickline; Samuel A. (St. Louis, MO)
Assignee: Barnes-Jewish Hospital (St. Louis, MO)
Application Number:10/302,369
Patent Claims:see list of patent claims

Details for Patent 7,186,399

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Try a Free Trial Barnes-Jewish Hospital (St. Louis, MO) 2036-04-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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