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Last Updated: December 8, 2021

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Patent: 7,149,631

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Summary for Patent: 7,149,631
Title:Alternative splicing and nonsense-mediated decay: computational methods and gene regulation
Abstract: Computational methods identify alternate splice forms of known gene transcripts and isoforms that are subject to NMD (nonsense-mediated decay). These methods were used to identify thousands of human genes that generate alternative splice forms, and to demonstrate that about a third of these are subject to NMD. This high prevalence of NMD-targeted transcripts indicates a systemic way of regulating gene expression--by shunting gene expression to nonproductive splice variants. This endemic regulation is exploited to engineer regulation of gene expression, to characterize splice pathway components and to assay splice environments, for example, using NMD-regulated reporter genes.
Inventor(s): Brenner; Steven E. (Oakland, CA), Green; Richard E. (Berkeley, CA), Lewis; Benjamin P. (Berkeley, CA)
Assignee: Regents of the University of California (Oakland, CA)
Application Number:10/159,997
Patent Claims:see list of patent claims

Details for Patent 7,149,631

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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