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Last Updated: September 30, 2020

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Patent: 7,098,373

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Summary for Patent: 7,098,373
Title:IL-18 transgenic animal
Abstract: Transgenic non-human mammals comprising a DNA with an exogenous IL-18 gene incorporated in it such that the exogenous IL-18 gene is skin-specifically expressed, or their offsprings. The transgenic non-human mammals according to the present invention spontaneously develop atopic dermatitis under specific pathogen-free conditions, and therefore, are useful as disease model animals. Use of the transgenic non-human mammals according to the present invention makes it possible to develop drugs for preventing or treating atopic dermatitis by natural immunity and also to elucidate the onset mechanisms of atopic diseases.
Inventor(s): Mizutani; Hitoshi (Tsui-shi Mie, JP)
Assignee: Mizutani; Hitoshi (Tsu, JP) Nakanishi; Kenji (Takarazuka, JP) Taiho Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:10/482,662
Patent Claims:see list of patent claims

Details for Patent 7,098,373

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Mizutani; Hitoshi (Tsu, JP) Nakanishi; Kenji (Takarazuka, JP) Taiho Pharmaceutical Co., Ltd. (Tokyo, JP) 2021-07-12 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Mizutani; Hitoshi (Tsu, JP) Nakanishi; Kenji (Takarazuka, JP) Taiho Pharmaceutical Co., Ltd. (Tokyo, JP) 2021-07-12 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Mizutani; Hitoshi (Tsu, JP) Nakanishi; Kenji (Takarazuka, JP) Taiho Pharmaceutical Co., Ltd. (Tokyo, JP) 2021-07-12 RX search
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial Mizutani; Hitoshi (Tsu, JP) Nakanishi; Kenji (Takarazuka, JP) Taiho Pharmaceutical Co., Ltd. (Tokyo, JP) 2021-07-12 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Mallinckrodt
Boehringer Ingelheim
Express Scripts
McKesson
McKinsey

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