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Generated: August 21, 2019

DrugPatentWatch Database Preview

Patent: 7,064,246

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Summary for Patent: 7,064,246
Title:Use of transposable elements for altering gene expression
Abstract: Methods of repressing expression of a recombinant gene in a cell are provided. The methods include the steps of introducing a transposase DNA binding motif into or adjacent to the gene, and introducing into the cell a transposase that is capable of binding to the transposase DNA binding motif. Methods of producing a population of cells of an organism that vary in their expression of a gene are also provided. The methods involve transfecting the cells with a first polynucleotide sequence encoding the target gene operably linked to a promoter such that the target gene is expressed in the cells, wherein the vector has at least one transposase DNA binding motif within or adjacent to the target gene; and transfecting some of the cells with a second polynucleotide encoding the transposable element operably linked to a second promoter such that the transposable element is expressed in the cells. In these methods, the target gene in the cells transfected with the second polynucleotide exhibits reduced expression when compared to the target gene in the cells that are not transfected with the second polynucleotide. Kits having a first polynucleotide with a gene and a DNA transposase binding motif in or adjacent to the gene, and a second polynucleotide comprising a gene encoding a transposase that is capable of binding to the transposase DNA binding motif are also provided.
Inventor(s): MacRae; Amy F. (St. Louis, MO)
Assignee:
Application Number:10/138,221
Patent Claims:see list of patent claims

Details for Patent 7,064,246

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Try a Free Trial Carnegie Institution of Washington (Washington, D.C.), entitled: \"Transposable elements and process for using same\", in which transposable elements isolated from maize are described, including Ac, and a process for using the same to identify and is 2021-05-01 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Try a Free Trial Carnegie Institution of Washington (Washington, D.C.), entitled: \"Transposable elements and process for using same\", in which transposable elements isolated from maize are described, including Ac, and a process for using the same to identify and is 2021-05-01 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Try a Free Trial Carnegie Institution of Washington (Washington, D.C.), entitled: \"Transposable elements and process for using same\", in which transposable elements isolated from maize are described, including Ac, and a process for using the same to identify and is 2021-05-01 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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