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Last Updated: September 27, 2020

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Patent: 7,064,243

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Summary for Patent: 7,064,243
Title:Screens and assays for agents useful in controlling parasitic nematodes
Abstract: The invention provides a method of identifying anti-nematode compounds and further provides transgenic nematodes that may be used to practice the method. In particular, the invention provides a screen for compounds that inhibit a nematode secretion pathway e.g, compounds that inhibit the secretion of proteins by nematodes. The transgenic nematodes express reporters for nematode secreted proteins. In preferred embodiments of the invention the screen is performed using C. elegans, i.e., certain embodiments of the invention utilize C. elegans and C. elegans secretory pathways as a model system for parasitic nematodes and parasitic nematode secretion pathways. The invention also provides pharmaceutical compositions that may be used in the treatment and prevention of nematode infection in humans and animals and anti-nematode agents that may be used to protect plants from plant-parasitic nematodes. In addition, the invention provides a genetic screen for identifying additional targets for anti-nematode compounds.
Inventor(s): Liu; Leo (Weston, MA), Burnam; Lucinda (Somerville, MA), Sluder; Ann (Burlington, MA), Link; Elizabeth (Brentwood, TN), Westlund; Beth (Brookline, MA)
Assignee: Cambria Biosciences LLC (Bedford, MA)
Application Number:10/051,644
Patent Claims:see list of patent claims

Details for Patent 7,064,243

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Cambria Biosciences LLC (Bedford, MA) 2021-01-18 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Cambria Biosciences LLC (Bedford, MA) 2021-01-18 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Cambria Biosciences LLC (Bedford, MA) 2021-01-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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