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Last Updated: December 1, 2021

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Patent: 7,015,328

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Summary for Patent: 7,015,328
Title:Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
Abstract: The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: ##STR00001## wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
Inventor(s): Cai; Sui Xiong (San Diego, CA), Zhang; Hong (San Diego, CA), Kemnitzer; William E. (San Diego, CA), Jiang; Songchun (San Diego, CA), Drewe; John (Carlsbad, CA), Storer; Richard (Pinner, GB)
Assignee: Cytovia, Inc. (San Diego, CA) Shire BioChem Inc. (Laval, CA)
Application Number:10/146,136
Patent Claims:see list of patent claims

Details for Patent 7,015,328

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 1997-11-26 ⤷  Try it Free 2021-05-16
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 2002-02-19 ⤷  Try it Free 2021-05-16
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Try it Free 2021-05-16
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Try it Free 2021-05-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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