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Last Updated: October 18, 2021

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Patent: 7,005,413

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Summary for Patent: 7,005,413
Title:Combination therapy for conditions leading to bone loss
Abstract: The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis. Methods of treatment are described using the polypeptides in conjunction with various agents, including IL-1 inhibitors, TNF-.alpha. inhibitors, and serine protease inhibitors.
Inventor(s): Boyle; William J. (Moorpark, CA), Lacey; David Lee (Newbury Park, CA), Calzone; Frank J. (Westlake Village, CA), Chang; Ming-Shi (Tainan, TW)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Application Number:09/613,591
Patent Claims:see list of patent claims

Details for Patent 7,005,413

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Immunex ENBREL etanercept SYRINGE 103795 1998-11-02 ⤷  Free Forever Trial Amgen Inc. (Thousand Oaks, CA) 2015-12-22 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 1998-11-02 ⤷  Free Forever Trial Amgen Inc. (Thousand Oaks, CA) 2015-12-22 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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