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Generated: July 19, 2019

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Patent: 6,958,215

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Summary for Patent: 6,958,215
Title: Methods and compositions for inhibition of RNA splicing
Abstract:A method of inhibiting the self-splicing of a Group I intron is disclosed. The method uses an oligonucleotide having a sequence essentially identical to a guide sequence found in the 5\' flanking exon and terminates with a 3\' ribonucleoside. Usually the oligonucleotide has N3\'.fwdarw.P5\' phosphoramidate or N3\'.fwdarw.P5\' thiophiosphoramidate linkages rather than phosphodiester linkages. A method of inhibiting the growth of organisms having Group I intron, particularly certain pathogenic fungi including P. carinii, C. albicans, and A. nidulans using the oglionucleotide is also provided.
Inventor(s): Testa; Stephen M. (Lexington, KY), Disney; Matthew D. (Rochester, NY), Gryaznov; Sergei M. (San Mateo, CA), Turner; Douglas H. (Pittsford, NY)
Assignee: Geron Corporation (Menlo Park, CA) The University of Rochester (Rochester, NY)
Application Number:09/936,146
Patent Claims:see list of patent claims

Details for Patent 6,958,215

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up Geron Corporation (Menlo Park, CA) The University of Rochester (Rochester, NY) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up Geron Corporation (Menlo Park, CA) The University of Rochester (Rochester, NY) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up Geron Corporation (Menlo Park, CA) The University of Rochester (Rochester, NY) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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