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Last Updated: October 1, 2020

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Patent: 6,951,844

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Summary for Patent: 6,951,844
Title: Phenyl naphthol ligands for thyroid hormone receptor
Abstract:New thyroid receptor ligands are provided which have the general formula I ##STR1## wherein R.sub.1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or unsubstituted C.sub.1-6 alkyl, or substituted or unsubstituted C.sub.3-7 cycloalkyl; R.sub.2 and R.sub.3 are each independently hydrogen, halogen, substituted or unsubstituted C.sub.1-4 alkyl, or substituted or unsubstituted C.sub.3-6 cycloalkyl, wherein at least one of R.sub.2 and R.sub.3 is other than hydrogen; R.sub.4 is a carboxylic acid selected from the group consisting of (CH.sub.2).sub.n COOH, (CH).sub.2 COOH, NHCO(CH.sub.2).sub.n COOH, CONH(CH.sub.2).sub.n COOH and NH(CH.sub.2).sub.m COOH; n is an integer from 0 to 4; and m is an integer from 1 to 4. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T.sub.3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.
Inventor(s): Hangeland; Jon J. (Morrisville, PA)
Assignee: Bristol Myers Squibb Company (Princeton, NJ)
Application Number:10/946,162
Patent Claims:see list of patent claims

Details for Patent 6,951,844

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Bristol Myers Squibb Company (Princeton, NJ) 2021-12-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Bristol Myers Squibb Company (Princeton, NJ) 2021-12-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Bristol Myers Squibb Company (Princeton, NJ) 2021-12-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Bristol Myers Squibb Company (Princeton, NJ) 2021-12-07 RX Orphan search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial Bristol Myers Squibb Company (Princeton, NJ) 2021-12-07 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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