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Last Updated: December 7, 2021

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Patent: 6,939,542

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Summary for Patent: 6,939,542
Title: Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vitreous body of the eye
Abstract:A thimerosal-free hyaluronidase preparation wherein the preferred hyaluronidase enzyme is devoid of molecular weight fractions below 40,000 MW, between 60-70,000 MW and above 100,000 MW. Also disclosed is a method for accelerating the clearance of hemorrhagic blood from the vitreous humor of the eye, said method comprising the step of contacting at least one hemorrhage-clearing enzyme (e.g., a .beta.-glucuronidase, matrix metalloproteinase, chondroitinase, chondroitin sulfatase or protein kinase) with the vitreous humor in an amount which is effective to cause accelerated clearance of blood therefrom.
Inventor(s): Karageozian; Hampar L. (San Juan Capistrano, CA), Karageozian; Vicken H. (San Juan Capistrano, CA), Kenney; Maria Cristina (Malibu, CA), Gutierrez Flores; Jose Luis (Tijuana, MX), Carpio Aragon; Gabriel Arturo (Tijuana, MX), Nesburn; Anthony B. (Malibu, CA)
Assignee: Ista Pharmaceuticals, Inc. (Irvine, CA)
Application Number:10/369,372
Patent Claims:see list of patent claims

Details for Patent 6,939,542

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 2004-05-05 ⤷  Try it Free 2015-11-22
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 2004-12-02 ⤷  Try it Free 2015-11-22
Amphastar Pharmaceuticals, Inc. AMPHADASE hyaluronidase Injection 021665 2004-10-26 ⤷  Try it Free 2015-11-22
Akorn, Inc. HYDASE hyaluronidase Injection 021716 2005-10-25 ⤷  Try it Free 2015-11-22
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live For Injection 125123 2006-05-25 ⤷  Try it Free 2015-11-22
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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