Patent: 6,939,376

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Summary for Patent: 6,939,376

Title:	Drug-delivery endovascular stent and method for treating restenosis
Abstract:	An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.
Inventor(s):	Shulze; John E. (Rancho Santa Margarita, CA), Betts; Ronald E. (La Jolla, CA), Savage; Douglas R. (Del Mar, CA)
Assignee:	Sun Biomedical, Ltd. (Hamilton Hm Ex, BM)
Application Number:	10/133,814
Patent Claims:	see list of patent claims

Details for Patent 6,939,376

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	01/16/1978	⤷ Try a Trial	2039-03-29
Janssen Biotech, Inc.	REOPRO	abciximab	Injection	103575	12/22/1994	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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