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Boehringer Ingelheim

Last Updated: February 21, 2020

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Patent: 6,939,376

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Summary for Patent: 6,939,376
Title: Drug-delivery endovascular stent and method for treating restenosis
Abstract:An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.
Inventor(s): Shulze; John E. (Rancho Santa Margarita, CA), Betts; Ronald E. (La Jolla, CA), Savage; Douglas R. (Del Mar, CA)
Assignee: Sun Biomedical, Ltd. (Hamilton Hm Ex, BM)
Application Number:10/133,814
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,939,376
Patent Claims:see list of patent claims

Details for Patent 6,939,376

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22   Start Trial Sun Biomedical, Ltd. (Hamilton Hm Ex, BM) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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