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Johnson and Johnson
Harvard Business School

Last Updated: June 4, 2023

Patent: 6,930,090

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Summary for Patent: 6,930,090
Title: Methods of activating a receptor using amphiphilic drug-oligomer conjugates
Abstract:The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (\"BBB\") and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugate comprises a therapeutic compound conjugated to an oligomer, wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety. The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and intermediates thereof, chemically coupled to amphiphilic oligomers.
Inventor(s): Ekwuribe; Nnochiri N. (Cary, NC), Radhakrishnan; Balasingam (Chapel Hill, NC), Price; Christopher H. (Chapel Hill, NC), Anderson, Jr.; Wes (Raleigh, NC), Ansari; Aslam M. (Durham, NC)
Assignee: Nobex Corporation (Durham, NC)
Application Number:10/716,975
Patent Claims:see list of patent claims

Details for Patent 6,930,090

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 01/10/1978 ⤷  Try a Trial 2018-08-14
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 01/23/2015 ⤷  Try a Trial 2018-08-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Harvard Business School
Boehringer Ingelheim

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