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Boehringer Ingelheim
Harvard Business School

Last Updated: December 6, 2021

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Patent: 6,923,968

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Summary for Patent: 6,923,968
Title: Cyclase inhibiting parathyroid hormone antagonists or modulators and osteoporosis
Abstract:The present invention relates to a novel method for treating a patient that has osteoporosis and the patient may be having administered cyclase activating parathyroid hormone (CAP) or analogues. The patient receives an administration of a cyclase inhibiting parathyroid hormone peptide (CIP) having an amino acid sequence from between (SEQ ID NO:1 [PTH.sub.2-84 ]) and (SEQ ID NO:3 [PTH.sub.34-84 ]) (i.e., a contiguous portion of PTH having an amino acid sequence set forth in SEQ ID NO:5 (PTH.sub.1-84), having the N-terminal amino acid residue starting at any position spanning from position 2 through position 34 of the PTH.sub.1-84, and the C-terminal amino acid residue ending at position 84 of the PTH.sub.1-84), (preferably (SEQ ID NO:2 [PTH.sub.3-84 ]) and (SEQ ID NO:8 [PTH.sub.28-84 ])), or a conservatively substituted variant thereof exhibiting parathyroid hormone (PTH) antagonist activity in a therapeutically effective, but non-toxic amount that reduces the occurrence of hypercalcemia or osteosarcoma in the patient resulting from the administration of CAP, and yet, through a CAP rebound effect, is effective in itself in the treatment of osteoporosis.
Inventor(s): Cantor; Thomas L. (El Cajon, CA)
Assignee: Scantibodies Laboratory, Inc. (Santee, CA)
Application Number:09/928,047
Patent Claims:see list of patent claims

Details for Patent 6,923,968

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 2015-01-23 ⤷  Free Forever Trial 2020-08-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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