Cyclase inhibiting parathyroid hormone antagonists or modulators and osteoporosis
The present invention relates to a novel method for treating a patient that has osteoporosis and the patient may be having administered cyclase activating parathyroid hormone (CAP) or analogues. The patient receives an administration of a cyclase inhibiting parathyroid hormone peptide (CIP) having an amino acid sequence from between (SEQ ID NO:1 [PTH.sub.2-84 ]) and (SEQ ID NO:3 [PTH.sub.34-84 ]) (i.e., a contiguous portion of PTH having an amino acid sequence set forth in SEQ ID NO:5 (PTH.sub.1-84), having the N-terminal amino acid residue starting at any position spanning from position 2 through position 34 of the PTH.sub.1-84, and the C-terminal amino acid residue ending at position 84 of the PTH.sub.1-84), (preferably (SEQ ID NO:2 [PTH.sub.3-84 ]) and (SEQ ID NO:8 [PTH.sub.28-84 ])), or a conservatively substituted variant thereof exhibiting parathyroid hormone (PTH) antagonist activity in a therapeutically effective, but non-toxic amount that reduces the occurrence of hypercalcemia or osteosarcoma in the patient resulting from the administration of CAP, and yet, through a CAP rebound effect, is effective in itself in the treatment of osteoporosis.
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