The invention relates to a genetic unit, optionally present as a multiple-copy, for inhibiting RNA. The unit contains the transcription units necessary for transcription by polymerase III and a DNA coding for inhibiting RNA, which is arranged within the unit in such a way that the transcribed RNA is part of the polymerase III transcript. Using these units it is possible to achieve increased stability of the inhibiting RNA, which may occur in the form of ribozymes or antisense-RNAs, whilst maintaining an undiminished activity. The invention further relates to a process for introducing the genetic units into the cell, the use of these units and pharmaceutical preparations containing them.
Beug; Hartmut (Vienna, AT), Birnstiel; Max L. (Vienna, AT), Cotten; Matthew (Vienna, AT), Wagner; Ernst (Langenzersdorf, AT), Kandolf; Harald (Vienna, AT)
Boehringer Inglheim International GmbH (Ingelheim am Rhein, DE)
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