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Last Updated: February 18, 2020

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Patent: 6,825,035

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Summary for Patent: 6,825,035
Title: Compositions and methods for modulating expression within smooth muscle cells
Abstract:The present invention relates to promoters, enhancers and other regulatory elements that direct expression within SMC, comprising nucleotide sequences from the 5\' regulatory region and the first intron, and transcriptionally active fragments thereof, that control expression of an SM .alpha.-A. Specifically provided are expression vectors, host cells and transgenic animals wherein an SM .alpha.-A regulatory region is capable of controlling expression of a heterologous gene, over-expressing an endogenous SMC gene or an inhibitor of a pathological process or knocking out expression of a specific gene believed to be important for an SM-related disease in SMC. The invention also relates to methods for using said vectors, cells and animals for screening candidate molecules for agonists and antagonists of disorders involving SMC. The invention further relates to compositions and methods for modulating expression of compounds within SMC, and to screening compounds that modulate expression within SMC. Methods for using the molecules and compounds identified by the screening assays for therapeutic treatments also are provided.
Inventor(s): Owens; Gary K. (Earlysville, VA), Mack; Christopher (Chapel Hill, NC), Blank; Randall (Charlottesville, VA)
Assignee: Setagon, Inc. (Charlottesville, VA)
Application Number:09/807,757
Patent Claims:see list of patent claims

Details for Patent 6,825,035

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Setagon, Inc. (Charlottesville, VA) 2018-10-23 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Setagon, Inc. (Charlottesville, VA) 2018-10-23 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Setagon, Inc. (Charlottesville, VA) 2018-10-23 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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