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Last Updated: December 5, 2021

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Patent: 6,824,972

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Summary for Patent: 6,824,972
Title: Diagnosis and treatment of medical conditions associated with defective NFkappa B(NF-.kappa.B) activation
Abstract:Incontinentia Pigmenti (IP) is a neurocutaneous genodermatosis that segregates as an X-linked dominant disorder with a high probability of prenatal male lethality. A locus in Xq28 containing NF-.kappa.B Essential Modulator, a gene product involved in the activation of NF-kB and central to many pro-inflammatory and apoptotic pathways, contains mutations in the majority of cases of IP. Disclosed are methods, compositions and kits directed to a defect in a NF-.kappa.B related disease such as IP.
Inventor(s): Kenwrick; Sue J. (Cambridge, GB), Woffendin; Hayley (Cambridge, GB), Munnich; Arnold (Paris, FR), Smahi; Asmae (Saint Ouen, FR), Israel; Alain (Paris, FR), Poustka; Annemarie (Heidelberg, 69120, DE), Heiss; Nina (Heidelberg, 69115, DE), D\'Urso; Michele (Naples, IT), Lewis; Richard A. (Houston, TX), Nelson; David L. (Houston, TX), Aradhya; Swaroop (Houston, TX), Levy; Moise (Houston, TX)
Assignee: Baylor College of Medicine (Houston, TX) Cambridge University Technical Services Limited (Cambridge, GB) Consiglio Nazionale Delle Richerche (Rome, IT) INSERM (Cedex 13, FR) L\'Institut Pasteur (Paris, FR) Poustka; Annemarie (Heidelberg, DE) Heiss; Nina (Heidelberg, DE)
Application Number:09/863,049
Patent Claims:see list of patent claims

Details for Patent 6,824,972

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2020-05-22
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2020-05-22
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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