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Last Updated: November 28, 2021

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Patent: 6,803,197

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Summary for Patent: 6,803,197
Title: Method for determining susceptibility to bone damage by screening polymorphisms in the vitamin D receptor gene
Abstract:The present invention relates to a prognostic method and means for determining susceptibility to bone damage in a subject, by screening for polymorphisms in the Vitamin D receptor or collagen I.alpha.1 genes. In particular, the method for determining susceptibility to bone damage comprises analyzing the genetic material of a subject to determine which of the B/b, A/a or T/t alleles of the restriction enzyme sites BsmI, ApaI and TaqI respectively are present. The method may further comprise determining which allele is present at die SpI restriction site of the collagen I.alpha.1 gene. Specific combinations of the above alleles represent a haplotype which is associated with susceptibility to bone damage.
Inventor(s): Uitterlinden; Andreas Gerardus (Poortugaal, NL), Van Leeuwen; Johannes Petrus Thomas Maria (Amstelveen, NL), Pols; Huibert Adriaan Pieter (Papendrecht, NL)
Assignee: Erasmus Universiteit Rotterdam (Rotterdam, NL)
Application Number:09/786,991
Patent Claims:see list of patent claims

Details for Patent 6,803,197

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2018-09-10
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2018-09-10
Emergent Biosolutions Canada Inc. BAT botulism antitoxin heptavalent (a, b, c, d, e, f, g) - (equine) Solution 125462 2013-03-22 ⤷  Free Forever Trial 2018-09-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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