An adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator. This viral vaccine can effectively prevent HIV infection when administered to humans either alone or as part of a prime and boost regime also with a vaccine plasmid.
Chen; Ling (Blue Bell, PA), Shiver; John W. (Doylestown, PA), Bett; Andrew J. (Lansdale, PA), Casimiro; Danilo R. (Harleysville, PA), Caulfield; Michael J. (Fort Washington, PA), Chastain; Michael A. (Glenside, PA), Emini; Emilio A. (Strafford, PA)
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