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Last Updated: November 27, 2021

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Patent: 6,740,655

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Summary for Patent: 6,740,655
Title: Pyrimidine carboxamides useful as inhibitors of PDE4 isozymes
Abstract:This invention is directed to compounds of the formula: ##STR1## wherein j is 0 or 1; k is 0 or 1; m is 0 or 1; n is 0 or 1; W is --O--; --S(.dbd.O).sub.t --, where t is 0, 1, or 2; or --N(R.sup.3)--; where R.sup.3 is --H, --(C.sub.1 -C.sub.3) alkyl, --OR.sup.12, phenyl, or benzyl; R.sup.C and R.sup.D have the same meaning as R.sup.A and R.sup.B, except that at least one of R.sup.C and R.sup.D must be --H; and the other variables are defined as set forth in the specification. The invention is also directed to pharmaceutical compositions comprising the above compounds and to methods of treating a subject suffering from a disease, disorder or condition mediated by the PDE4 isozyme, the method comprising administering a therapeutically effective amount of a compound as described above. The invention is particularly directed to methods of treating inflammatory, respiratory and allergic diseases and conditions, especially asthma; chronic obstructive pulmonary disease (COPD) including chronic bronchitis, emphysema, and bronchiectasis; chronic rhinitis; and chronic sinusitis.
Inventor(s): Magee; Thomas Victor (Mystic, CT), Marfat; Anthony (Mystic, CT), Chambers; Robert James (Mystic, CT)
Assignee: Pfizer Inc (New York, NY)
Application Number:10/181,417
Patent Claims:see list of patent claims

Details for Patent 6,740,655

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Try it Free 2017-04-04
Janssen Biotech, Inc. REMICADE infliximab For Injection 103772 1998-08-24 ⤷  Try it Free 2017-04-04
Immunex Corporation ENBREL etanercept For Injection 103795 1998-11-02 ⤷  Try it Free 2017-04-04
Immunex Corporation ENBREL etanercept For Injection 103795 1999-05-27 ⤷  Try it Free 2017-04-04
Immunex Corporation ENBREL etanercept Injection 103795 2004-09-27 ⤷  Try it Free 2017-04-04
Immunex Corporation ENBREL etanercept Injection 103795 2007-02-01 ⤷  Try it Free 2017-04-04
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Express Scripts
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Harvard Business School

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