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Last Updated: September 30, 2020

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Patent: 6,719,981

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Summary for Patent: 6,719,981
Title: Stable, attenuated rabies virus mutants and live vaccines thereof
Abstract:The present invention relates to recombinant rabies virus mutants comprising a mutation in the viral genome, whereby said mutation comprises at least a substitution of the Arg.sub.333 codon in the gene encoding the G protein with a codon that differs by three nucleotides from said Arg.sub.333 codon. These rabies virus mutants have a glycoprotein G that comprises an amino acid at position 333 which is encoded by a codon that differs by all three nucleotides from the Arg codon in amino acid position 333 in the glycoprotein of the parental virus. Said recombinant rabies virus mutants are stable and non-pathogenic in immune competent animals and are suitable for use in a live, attenuated anti-rabis vaccine.
Inventor(s): Mebatsion; Teshome T (Boxmeer, NL), Conzelmann; Karl Klaus (Neuried, DE)
Assignee: Akzo Nobel N.V. (Arnhem, NL)
Application Number:09/856,653
Patent Claims:see list of patent claims

Details for Patent 6,719,981

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Glaxosmithkline Biologicals Sa RABAVERT rabies vaccine KIT 103334 1 2016-12-19   Start Trial Akzo Nobel N.V. (Arnhem, NL) 2018-11-27 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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