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Boehringer Ingelheim

Last Updated: July 2, 2020

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Patent: 6,717,031

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Summary for Patent: 6,717,031
Title: Method for selecting a transgenic mouse model of alzheimer\'s disease
Abstract:The construction of transgenic animal models of human Alzheimer\'s disease, and methods of using the models to screen potential Alzheimer\'s disease therapeutics, are described. The models are characterized by pathologies similar to pathologies observed in Alzheimer\'s disease, based on expression of all three forms of the .beta.-amyloid precursor protein (APP), APP695, APP751, and APP770, as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer\'s disease (FAD) mutations at amino acid 717, predicted mutations in the APP gene, and truncated forms of APP that contain the A.beta. region. Animal cells can be isolated from the transgenic animals or prepared using the same constructs with standard techniques such as lipofection or electroporation. The transgenic animals, or animal cells, are used to screen for compounds altering the pathological course of Alzheimer\'s disease as measured by their effect on the amount of APP, .beta.-amyloid peptide, and numerous other Alzheimer\'s disease markers in the animals, the neuropathology of the animals, as well as by behavioral alterations in the animals.
Inventor(s): Games; Kate Dora (San Francisco, CA), Schenk; Dale Bernard (Pacifica, CA), McConlogue; Lisa Claire (San Francisco, CA), Seubert; Peter Andrew (S. San Francisco, CA), Rydel; Russell E. (Belmont, CA)
Application Number:09/149,718
Patent Claims:see list of patent claims

Details for Patent 6,717,031

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial 2015-06-07 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial 2015-06-07 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial 2015-06-07 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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