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Last Updated: February 23, 2020

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Patent: 6,689,566

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Summary for Patent: 6,689,566
Title: Methods, kits, and antibodies for detecting parathyroid hormone
Abstract:The present invention relates to novel methods and devices for detecting whole or non-fragmented parathyroid hormone (wPTH) in a biological sample. In particular, a novel monoclonal or polyclonal antibody or antibody fragment is used that is specific for a portion of the initial peptide sequence for wPTH which comprises a domain for adenylate cyclase activation, (amino acids 2 to 8), wherein at least four amino acids in this sequence are part of the reactive portion with the antibody. The present wPTH assay can differentiate between the complete 1 to 84 amino acid sequence form of PTH and a large but incomplete 7 to 84 amino acid sequence form of PTH that is measured by commercially available \"intact\" or I-PTH assays. Measurement of both the complete biologically active form of PTH and the large but biologically inactive form of PTH can lead to the misdiagnosis of the parathyroid function in patients.
Inventor(s): Cantor; Thomas L. (El Cajon, CA), Gao; Ping (San Diego, CA)
Assignee: Scantibodies Laboratory, Inc. (Santee, CA)
Application Number:09/231,422
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,689,566
Patent Claims:see list of patent claims

Details for Patent 6,689,566

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Scantibodies Laboratory, Inc. (Santee, CA) 2039-03-29 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Scantibodies Laboratory, Inc. (Santee, CA) 2039-03-29 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Scantibodies Laboratory, Inc. (Santee, CA) 2039-03-29 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Scantibodies Laboratory, Inc. (Santee, CA) 2039-03-29 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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