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Last Updated: September 30, 2020

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Patent: 6,686,382

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Summary for Patent: 6,686,382
Title: Sulfonamides and derivatives thereof that modulate the activity of endothelin
Abstract:Thienyl-, furyl-, pyrrolyl- and phenylsulfonamides, formulations of pharmaceutically-acceptable derivatives thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides, N-(isoxazolyl)pyrrolylsulfonamides and N-(isoxazolyl)phenylsulfonamides, formulations thereof and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or pharmaceutically acceptable derivatives thereof that inhibit the activity of endothelin are also provided.
Inventor(s): Wu; Chengde (Pearland, TX), Blok; Natalie (Houston, TX), Holland; George W. (North Caldwell, NJ)
Assignee: Encysive Pharmaceuticals Inc. (Bellaire, TX)
Application Number:09/751,825
Patent Claims:see list of patent claims

Details for Patent 6,686,382

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial Encysive Pharmaceuticals Inc. (Bellaire, TX) 2019-12-31 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial Encysive Pharmaceuticals Inc. (Bellaire, TX) 2019-12-31 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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