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Last Updated: September 18, 2020

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Patent: 6,680,068

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Summary for Patent: 6,680,068
Title: Drug delivery formulations and targeting
Abstract:The invention is based on the discovery that angiogenic vessels have heterogeneous surface charge and that cationic liposomes actually target human tumor blood vessels only in irregularly shaped patches. The invention thus features methods for delivering therapeutic compounds to angiogenic vascular endothelial surfaces using a mixture, or \"cocktail\", of positively charged and neutral liposomes. The new methods can be used to target multiple regions on the same tumor vessel and/or clusters of vessels within the same tumor. Liposomes with different chemical and/or physical properties (e.g., charge, stability, solubility, diameter) can be delivered simultaneously, and can target tumor vessels and other angiogenic vessels with greater efficiency compared to cationic liposomes alone.
Inventor(s): Campbell; Robert B. (Boston, MA), Jain; Rakesh K. (Boston, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Application Number:09/898,107
Patent Claims:see list of patent claims

Details for Patent 6,680,068

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial The General Hospital Corporation (Boston, MA) 2020-07-06 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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