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Last Updated: September 21, 2020

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Patent: 6,673,574

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Summary for Patent: 6,673,574
Title: Oral delivery of peptides using enzyme-cleavable membrane translocators
Abstract:Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine in addition to having the active peptide linked to a membrane translocator which is capable of being at least partially cleaved in vivo by an enzyme. The composition includes an acid-resistant protective vehicle which transports components of the invention through the stomach and a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.
Inventor(s): Stern; William (Tenafly, NJ), Mehta; Nozer M. (Randolph, NJ), Ray; Martha V. L. (Nutley, NJ)
Assignee: Unigene Laboratories Inc. (Fairfield, NJ)
Application Number:09/997,465
Patent Claims:see list of patent claims

Details for Patent 6,673,574

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Unigene Laboratories Inc. (Fairfield, NJ) 2020-11-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Unigene Laboratories Inc. (Fairfield, NJ) 2020-11-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Unigene Laboratories Inc. (Fairfield, NJ) 2020-11-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Unigene Laboratories Inc. (Fairfield, NJ) 2020-11-30 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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